What’s New in COMT


  • Fibroids feed on oestrogen — and early perimenopause is when oestrogen runs highest and least opposed. As ovulation skips and progesterone crashes (the Progesterone Shift), oestrogen dominates, and the growth it drives is amplified by…


  • Sudden perimenopausal anxiety and worsening ADHD in early perimenopause are driven by a biochemical traffic jam. As progesterone drops and heavy bleeding drains iron, chaotic oestrogen spikes actively suppress the COMT enzyme, trapping adrenaline in your body.…