What’s New in progesterone shift

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    Sudden perimenopausal anxiety and worsening ADHD in early perimenopause are driven by a biochemical traffic jam. As progesterone drops and heavy bleeding drains iron, chaotic oestrogen spikes actively suppress the COMT enzyme, trapping adrenaline in your body.…

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    Breast tenderness in early perimenopause is caused by the Progesterone Shift: oestrogen continues stimulating breast tissue while progesterone — normally produced after ovulation to moderate that effect — is absent or insufficient, producing swelling, heaviness,…

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    In Short: Perimenopause bloating appears because the gut is exquisitely sensitive to progesterone loss — as anovulatory cycles increase, gut transit slows, gas accumulates, and mast cell reactivity in the gut wall drives histamine-mediated distension.…

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    Heavy and flooding periods in early perimenopause occur because anovulatory cycles produce no progesterone, allowing the womb lining – the endometrium – to thicken without progesterone to provide the scaffolding — and when that lining…

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    Early perimenopause is defined by the Progesterone Shift — as ovulation becomes increasingly unreliable, the luteal phase produces no progesterone, creating oestrogen dominance that drives heavy periods, breast tenderness, anxiety, insomnia, and mood changes in…