Impacts of psychological stress on osteoporosis: clinical implications and treatment interactions
While osteoporosis and psychological stress occur via differing mechanisms, there are several potential molecular links that exist between a pathological response to stress and the development of bone disease. Although not a comprehensive list, these may include dysregulation of the HPA-axis and SAM pathway, inflammatory pathways, IGF signaling, estrogen, serotonin, GABA, and RANKL.
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This study looked at more than 7,000 women over 60 in the US (NHANES 2005–2020) to understand how the age at menopause relates to depression in later life,…
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3,000 women were followed for 10 years to ask a simple question: does the menopausal transition itself increase the risk of significant anxiety symptoms? What was…
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This long-term study followed 233 women from before menopause to after their final period to see how different types of anxiety relate to hot flushes.…
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This study followed 122 late peri‑ and postmenopausal women (average age 59) to see how their sleep relates to early brain changes that raise the…
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An analysis of whether “moderate” alcohol intake (even within current guidelines) is linked to higher iron in the brain and, in turn, to worse cognitive…
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Age‑related cognitive decline, including Alzheimer’s disease, can be understood as a myelin problem rather than only a “plaques and tangles” problem. Myelin is the fatty insulation around…
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In a small number of animal species, females cease reproducing long before the end of their natural lifespan. A prolonged post‑reproductive life stage is exceptionally…
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Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has…
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While osteoporosis and psychological stress occur via differing mechanisms, there are several potential molecular links that exist between a pathological response to stress and the…
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Excess glucocorticoids are well recognised as a cause of osteoporosis; they inhibit osteoblast function and increase osteoblast and osteocyte apoptosis resulting in thinning of the…
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Osteoporosis, a consequence of menopause in the biological cycle of women, emerges with the conclusion of reproductive capabi lities.Hormonal changes during this phase contribute to…
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The purpose of this study was to determine the longitudinal association between menopausal vasomotor symptoms (VMS) and urinary N-telopeptide level (NTX) according to menopausal stage. We…
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Objective: To determine whether women with vasomotor symptoms (VMS) have lower bone mineral density (BMD) than women without VMS. Design We analyzed data from baseline…
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Background: Osteocalcin, has high affinity for calcium. In osteoporotic women, deficiency of calcium may lead to lowering of the formation of hydroxyapatite crystals. Thus, in the…
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A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment represents a transition between normal cognition and dementia. The frequency of cognitive changes is…