What’s New in Insulin Signalling

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    Postmenopausal sarcopenia and Alzheimer’s disease: The interplay of mitochondria, insulin resistance, and myokines

    Postmenopausal sarcopenia and Alzheimer’s disease (AD) are linked through a shared muscle–brain metabolic pathway. It highlights that women make up around two‑thirds of AD cases and that more than 60% are postmenopausal, then argues that…

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    Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders

    A hormone made by bone, osteocalcin, helps regulate blood sugar, mood, memory and movement by acting on the brain as well as the rest of the body. In animal and human data, low osteocalcin is…

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    Lupron, Brain Function, and the Keto Diet

    In the absence of estradiol, brain glucose transport diminishes significantly. This effectively starves the brain for energy inducing severe bioenergetic deficiencies with all of the concordant neuronal damage one might expect. The reduction in glucose…

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    Estrogen: A master regulator of bioenergetic systems in the brain and body

    Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function to generate ATP. In the body, estrogen protects…

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    Tank Estradiol and Lose Metabolic Flexibility: Pitfalls of Lupron and Oophorectomy

    Steroid hormones regulate metabolic flexibility at the level of the mitochondria. Estradiol, the most frequently studied among the steroid hormones, plays a pivotal role in determining how food fuel is converted into cellular fuel or…

From my Substack

I write regularly about menopause, symptoms, biology, and the wider story women are so often not told. Some of the articles will be part of my book. If you want to go deeper into the thinking behind my work, you can start here.

The Ultimate Guide to Perimenopause and Menopause: Making Sense of the Chaos
Perimenopause and the ADHD Shift

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Sandra Ishkanes  Natural Menopause Specialist based in Brighton, serving clients worldwide via Online Consultations   
BSc Molecular Biology (King’s College London) | DipION | Functional Medicine Practitioner
Registered member, Association of Naturopathic Practitioners (ANP) – the UK professional body for accredited naturopathic and functional medicine practitioners. ANP members hold accredited qualifications, carry professional indemnity insurance, and follow a strict code of ethics.

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The information provided on this website is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Sandra Ishkanes is a Functional Medicine Practitioner and Molecular Biologist, not a medical doctor. Always seek the advice of your GP or other qualified healthcare provider with any questions you may have regarding a medical condition or before making any changes to your diet, lifestyle, or supplement regimen—especially if you are currently taking prescription medication or HRT. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.